What Is The Endocannabinoid System?

The endocannabinoid system is the system of cannabinoid receptors within the human body. Let's quickly look to understand what these receptors are exactly.

Cannabinoid receptors are sites located all throughout the body, there are two receptor types: CB1 and CB2. Cannabinoid receptor type 1 (CB1) is expressed in the brain (central nervous system), heart, lungs, liver and kidneys, whilst cannabinoid receptor type 2 (CB2) is expressed mainly in the immune system but also in the brain.


These sites bind with cannabinoids to promote the proper physiological function of the muscular system, immune system, nervous system and more. CB1 and CB2 work together playing a role in many different physiological process, including mood, memory, appetite and pain reception. Humans actually create a type of cannabinoid, known as an endocannabinoid, naturally within the body and when introduced to these receptors, the receptors activate and produce physiological changes.

It is also shown in science and through human experience that phytocannabinoids (these are plant derived cannabinoids), such as THC and CBD, interact with the human endocannabinoid system.

So we've covered the foundations, now let's start to develop this further by looking more into how CBD interacts with the endocannabinoid system.

The Endocannabinoid System & CBD

Whilst THC has a strong binding affinity for both CB1 and CB2 receptors, cannabidiol (CBD) has no particular binding affinity. This doesn't mean that there is no benefit, instead many of the benefits of CBD are created through indirect actions.

These indirect actions include activating TRPV1 receptors which are involved in regulating pain, body temperature and inflammation.

CBD also works to slow production of Fatty Acid Amide Hydrolase (FAAH) which in turn creates higher levels of endocannabinoids. One endocannabinoid in particular is Anandamide (also known as the bliss molecule), which plays a role in the neural generation of pleasure and other important functions such as regulating feeding behaviours.

Knowing that the human endocannabinoid system is receptive to phytocannabinoids (plant based cannabinoids), it makes it possible to supplement CBD intake.

There are a range of ways that you can supplement CBD through the use of CBD products. CBD products come in many forms, whether it be CBD oils, capsules, gummies, sublingual sprays or topicals.

Finding the right CBD product for you is important. It's all about working within your routine and supplementing your lifestyle, doing so in a way that you enjoy.

We specialise in a natural CBD oil, consisting of pure CBD distillate and an MCT carrier oil.

Creating this product requires knowledge, and in doing so we've read, researched, discussed, debated, explored and experienced CBD. We've put ourselves in a position to talk comfortably about this, and we're always looking to share our knowledge and experience with others.

If you're curious about CBD, or simply want to chat a little more on the topic, get in touch by heading over to our contact page – otherwise you can reach us on social (@thepracticecbd).

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